Biomolecular electronics
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Identified the relationship of structure with electron transport in peptide on solid state, especially the role of side chains.
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Elucidated the energy level shifting of dipeptide in the process from gas phase to solid state surface.
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Constructed DNA-based single molecular rectifier for molecular electronics.
Biomolecular imaging & recognition
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With multiple methods including STM imaging, AFM recognition imaging, and force spectroscopy to probe heparin-FX06 interaction at single-molecular level.
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Identified single-molecular antithrombin-heparin interaction on different endothelial cell surfaces by AFM based force spectroscopy.
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Applying aptamer modified AFM tip for the AFM recognition imaging of ricin.
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Prepared the surface relevant regulable DNA toroids; with AFM technique, studied the behavior of DNA-dopamine complex in solution and on the liquid-solid interface.
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Demonstrated the low temperature induced disassembly of the filaments consisting of DNA and RecA recombinase on the mica surface by AFM imaging.
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Examined the inhibition of cationic polyelectrolyte (i.e., poly-L-lysine) on the RecA-DNA filaments formation to understand the reaction mechanism.
Bio-inorganic hybrid materials
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Synthesized a novel fluorescent silver cluster via protein-directed approach and used it for mercury (II) ion detection.
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Improved the properties of graphene oxide through modification with different molecules; studied their effects on mammalian cell.
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Functionalized gold nanoparticles with Raman tag and protein for DNA methylation detection.